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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">TOMBU</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable infobox float-right" id="Vorlage_Infobox_Chemikalie" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Chemikalie">
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Strukturformel
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Allgemeines
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<td style="width:33%;">Name
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<td>TOMBU
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<td><a href="Summenformel" title="Summenformel">Summenformel</a>
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<td>C<sub>11</sub>F<sub>6</sub>H<sub>18</sub>N<sub>5</sub>O<sub>4</sub>P
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<td>Kurzbeschreibung
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<p>farbloses Pulver<sup id="cite_ref-Jad_1-0" class="reference"><a href="#cite_note-Jad-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Externe Identifikatoren/Datenbanken
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<td style="width:33%;"><a href="CAS-Nummer" title="CAS-Nummer">CAS-Nummer</a>
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<td><span title="Untervorlage eingebunden: CASRN"></span><span class="KeinCASLink" title="CAS-Nummer ohne Common-Chemistry-Eintrag">1654761-94-0</span><span class="editoronly" style="display:none;"></span>
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<td style="border-right:1px solid #a2a9b1;"><a href="Wikidata" title="Wikidata">Wikidata</a>
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<td colspan="2"><a href="https://www.wikidata.org/wiki/Q27902938" class="extiw external" title="d:Q27902938">Q27902938</a>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Eigenschaften
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<td><a href="Molare_Masse" title="Molare Masse">Molare Masse</a>
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<td>429,26 g·mol<sup>−1</sup>
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<td><a href="Aggregatzustand" title="Aggregatzustand">Aggregatzustand</a>
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<p>fest
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<td><a href="Schmelzpunkt" title="Schmelzpunkt">Schmelzpunkt</a>
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<p>199–200 °C (Zersetzung)<sup id="cite_ref-Jad_1-1" class="reference"><a href="#cite_note-Jad-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Sicherheitshinweise
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<td colspan="2" style="text-align:center"><b><a href="Global_harmonisiertes_System_zur_Einstufung_und_Kennzeichnung_von_Chemikalien" title="Global harmonisiertes System zur Einstufung und Kennzeichnung von Chemikalien">GHS-Gefahrstoffkennzeichnung</a></b><br><i>keine Einstufung verfügbar</i><sup id="cite_ref-NV_2-0" class="reference"><a href="#cite_note-NV-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
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<td colspan="2" style="background:#FFDEAD; color:#202122; font-size:80%; text-align:center; line-height:150%; padding:.25em;">Wenn nicht anders vermerkt, gelten die angegebenen Daten bei <a href="Standardbedingungen" title="Standardbedingungen">Standardbedingungen</a> (0 °C, 1000 hPa).
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</p><p><b>TOMBU</b> (<i>N</i>-{[1,3-Dimethyl-2,4,6-trioxotetrahydropyrimidin-5(6<i>H</i>)-ylidenaminooxy](dimethylamino)methylen}-<i>N</i>-methylmethanaminiumhexafluorophosphat) ist ein <a href="Kupplungsreagenz" title="Kupplungsreagenz">Kupplungsreagenz</a>, welches in der <a href="Peptidsynthese" title="Peptidsynthese">Peptidsynthese</a> zur Erzeugung von <a href="Peptid" title="Peptid">Peptiden</a> verwendet wird.<sup id="cite_ref-Jad_1-2" class="reference"><a href="#cite_note-Jad-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Es ist ein <a href="Derivat_(Chemie)" title="Derivat (Chemie)">Derivat</a> von <a href="Oxyma" class="mw-redirect" title="Oxyma">Oxyma</a>-B.<sup id="cite_ref-Jad_1-3" class="reference"><a href="#cite_note-Jad-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p><p>Alternative Kopplungsreagenzien sind z. B. <a href="HATU" title="HATU">HATU</a>, <a href="HBTU" title="HBTU">HBTU</a>, <a href="HCTU" title="HCTU">HCTU</a>,<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> <a href="TBTU" class="mw-redirect" title="TBTU">TBTU</a>, <a href="COMBU" title="COMBU">COMBU</a><sup id="cite_ref-Jad_1-4" class="reference"><a href="#cite_note-Jad-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> und <a href="COMU" title="COMU">COMU</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-Jad-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Jad_1-0">a</a></sup> <sup><a href="#cite_ref-Jad_1-1">b</a></sup> <sup><a href="#cite_ref-Jad_1-2">c</a></sup> <sup><a href="#cite_ref-Jad_1-3">d</a></sup> <sup><a href="#cite_ref-Jad_1-4">e</a></sup></span> <span class="reference-text">Y. E. Jad, S. N. Khattab, B. G. de la Torre, T. Govender, H. G. Kruger, A. El-Faham, F. Albericio: <i>TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.</i> In: <i><a href="Molecules" title="Molecules">Molecules</a>.</i> Band 19, Nummer 11, 2014, S. 18953–18965, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3390/molecules191118953">10.3390/molecules191118953</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25412042?dopt=Abstract">PMID 25412042</a>.</span>
</li>
<li id="cite_note-NV-2"><span class="mw-cite-backlink"><a href="#cite_ref-NV_2-0">↑</a></span> <span class="reference-text">Dieser Stoff wurde in Bezug auf seine Gefährlichkeit entweder noch nicht eingestuft oder eine verlässliche und zitierfähige Quelle hierzu wurde noch nicht gefunden.</span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">C. U. Hjørringgaard, A. Brust, P. F. Alewood: <i>Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis.</i> In: <i><a href="Journal_of_Peptide_Science" title="Journal of Peptide Science">Journal of Peptide Science</a>.</i> Band 18, Nummer 3, März 2012, S. 199–207, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/psc.1438">10.1002/psc.1438</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/22252935?dopt=Abstract">PMID 22252935</a>.</span>
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